A Guide to Acanthosis Nigricans Treatment
- Blog Admin

- Sep 24, 2025
- 15 min read
An effective acanthosis nigricans treatment starts with a simple but crucial understanding: those dark, velvety patches on your skin aren't the real problem. They're a signal.
Think of it as your body sending up a flare, letting you know there's a deeper issue that needs attention. The most direct path to clearing your skin—and boosting your overall health—is to address the root cause, whether it's insulin resistance or a hormonal imbalance. Once that's underway, advanced cosmetic treatments like the Aerolase laser can step in to quickly and safely restore your skin's natural, even tone. Here at Skinsation Aesthetics in London, Ontario, we consider Aerolase the top solution for tackling the cosmetic appearance of acanthosis nigricans.
So, What Exactly Is Acanthosis Nigricans?

If you've noticed dark, thick, almost velvety patches of skin, usually in body folds like your neck, armpits, or groin, you're likely seeing acanthosis nigricans (AN). It's so important to remember that AN isn't a disease in itself. It’s a skin manifestation—a visible sign that something else is happening inside your body.
The most common culprit behind AN in Canada is insulin resistance. This happens when your body's cells stop responding properly to the hormone insulin. To get the message through, your pancreas goes into overdrive and produces even more. This flood of excess insulin can act like a growth stimulant for your skin cells, causing them to multiply rapidly and create those characteristic dark, thickened patches.
The Link Between Insulin, Weight, and Your Skin
There's a very strong connection between insulin resistance, body weight, and the appearance of AN. A significant number of Canadian adults live with excess weight, which is a primary risk factor for developing insulin resistance and, eventually, type 2 diabetes.
When you have insulin resistance, high levels of insulin are constantly circulating in your bloodstream. This overstimulation is what physically creates the signs of acanthosis nigricans.
This isn't just a local phenomenon; it's a North American one. For example, recent Canadian health data indicates a rising trend in obesity and related metabolic conditions, mirroring patterns seen across the continent. This connection highlights that for many Canadians, acanthosis nigricans treatment must focus on managing insulin resistance and weight first. It's a clear demonstration of how tackling these core health issues is the key to resolving the skin condition.
Getting to the Root Cause
While insulin resistance is the most frequent trigger, it's not the only one. Understanding all the potential causes is the only way to find the right treatment plan for you.
To help you connect the dots, we've put together a table outlining the most common triggers and underlying conditions associated with acanthosis nigricans.
Common Triggers and Underlying Causes of Acanthosis Nigricans
Cause | Description | Commonly Associated With |
|---|---|---|
Insulin Resistance | The body's cells don't respond well to insulin, leading to higher insulin levels in the blood. | Obesity, pre-diabetes, type 2 diabetes. |
Hormonal Imbalances | Conditions that disrupt the body's normal hormone levels. | Polycystic Ovary Syndrome (PCOS), underactive thyroid. |
Medications | Certain drugs can cause AN as a side effect. | High-dose niacin, corticosteroids, some birth control pills. |
Heredity | A genetic predisposition where AN appears without other health issues. | Familial acanthosis nigricans. |
Cancer (Rare) | A sudden, severe onset of AN can be a sign of an internal malignancy. | Most often stomach, colon, or liver cancer. |
This table can be a helpful starting point, but it's crucial to work with a professional for an accurate diagnosis. Here's a bit more on what those causes look like:
Hormonal Issues: Conditions like Polycystic Ovary Syndrome (PCOS) are often intertwined with insulin resistance and can trigger AN. Getting to the bottom of your hormonal health is a vital first step, and tools like a PCOS Clarity test can offer incredibly valuable insights.
Specific Medications: Some common medications can induce AN, including high-dose niacin, corticosteroids, and even certain types of birth control pills.
Genetics: Sometimes, it just runs in the family. In these cases, AN can be a genetic trait that appears without any other underlying health problems.
Rare, Serious Conditions: It's very rare, but a sudden and severe appearance of AN can be linked to certain internal cancers, especially stomach cancer. This is why any new or rapidly changing skin patches should always be checked out by a professional right away.
Ultimately, the first and most critical step is figuring out why you have acanthosis nigricans. Once that root cause is pinpointed, you and your skincare specialist can build a targeted plan that not only improves how your skin looks but also supports your long-term health and well-being.
Practical Lifestyle Changes That Make a Difference
While advanced options like Aerolase can dramatically improve your skin's appearance, the most sustainable acanthosis nigricans treatment strategy really begins at home. The path to clearer skin is deeply intertwined with your daily habits. Making practical, consistent lifestyle shifts is the single most important step you can take to manage the root causes of AN.
This isn't about chasing perfection—it's about making progress. You'd be surprised how small, consistent changes can have a major impact on your insulin sensitivity and, in turn, on the visibility of those dark, velvety patches.
Rethink Your Plate for Better Insulin Control
Your diet is one of the most powerful tools you have. The main goal here is to stabilize your blood sugar and insulin levels by steering clear of foods that cause sharp spikes. This means embracing a low-glycemic approach, which prioritizes foods that your body digests more slowly.
Let's break it down into practical terms:
Swap refined grains for whole ones: Instead of white bread or pasta, try sprouted grain bread, quinoa, or brown rice.
Choose smarter snacks: A handful of berries, which are loaded with fibre and antioxidants, is a far better choice than a sugary granola bar or dried fruit.
Build balanced meals: Make sure every meal has a good source of protein (like chicken, fish, or legumes), healthy fats (think avocado, nuts, and olive oil), and plenty of fibre from vegetables. This trio works together to slow down sugar absorption.
These simple swaps help your body manage insulin much more effectively, which directly addresses the primary trigger for most cases of acanthosis nigricans.
Addressing the underlying cause is paramount. Research confirms that lifestyle intervention remains a cornerstone of effective management. Structured weight loss programs that include dietary changes and increased physical activity have been shown to lead to lesion improvement in about 55% of patients within just four to six months. You can discover more insights about these findings on StatPearls.com.
Get Moving in a Way You Enjoy
You don't need to spend countless hours at the gym to see results. The real key is finding a type of movement you genuinely enjoy because that’s what you’ll stick with. For our local clients here in London, Ontario, that could be a brisk walk through the beautiful trails at Springbank Park or joining a fun yoga class downtown.
Movement improves how your body uses insulin, making your cells more sensitive to it. This means your pancreas doesn't have to work overtime producing excess amounts, which helps calm the overactive skin cell production that causes AN in the first place.
Try to aim for about 30 minutes of moderate activity most days of the week. This could be anything from:
Cycling
Swimming
Dancing
Strength training
Even tiny changes, like choosing the stairs over the elevator, really do add up over time.
Why a Modest Weight Loss Delivers Big Results
For many people, even a small reduction in body weight can make a world of difference. Research shows that losing just 5-10% of your total body weight can significantly improve insulin sensitivity. This reduction can directly lead to the lightening and softening of acanthosis nigricans patches.
This is incredibly empowering because it puts the control right back in your hands. It reframes weight management not as some massive, overwhelming challenge, but as a series of small, achievable steps that have a direct and visible impact on your skin's health. By combining these smart lifestyle choices, you're not just treating a symptom—you're building a healthier foundation from the inside out.
Diving Into Topical and Medical Skin Treatments

While you’re tackling the internal triggers of acanthosis nigricans with those important lifestyle changes, you can also get to work on your skin's appearance. Think of it as a two-pronged attack. Targeted topical and medical treatments work directly on the surface to lessen the thickness and dark colouring of AN, which can be a real confidence booster while your body heals from the inside out.
Here in Canada, there are some fantastic options available, from over-the-counter creams to more powerful prescription solutions. The real key is knowing what these treatments do and how they fit into your overall acanthosis nigricans treatment plan. However, for faster and more significant results, Aerolase laser treatment often proves superior.
Topical Treatments for Smoother Skin
When it comes to managing the look and feel of AN, topical treatments are usually the first thing we reach for. Their main job is to exfoliate that thickened skin and lighten up the dark patches.
You'll find a few standout ingredients in creams and lotions that really get the job done:
Retinoids (like Tretinoin): These vitamin A derivatives are absolute workhorses in dermatology. They accelerate skin cell turnover, helping to slough off the thick, hyperpigmented outer layer and bring fresh, healthier-looking skin to the surface. For the best results, prescription-strength retinoids are typically the way to go.
Urea: This ingredient is a brilliant keratolytic, which is a fancy way of saying it breaks down the excess keratin protein in the skin. A cream with 10-20% urea can do wonders for softening and thinning out those rough, velvety patches.
Alpha Hydroxy Acids (AHAs) & Beta Hydroxy Acids (BHAs): Think of ingredients like glycolic acid (an AHA) and salicylic acid (a BHA) as chemical exfoliants. They work by dissolving the "glue" that holds dead skin cells together, which helps reduce the skin's thickness and improve its texture over time.
A quick word of advice: topicals aren't an overnight miracle. Consistency is everything. You'll likely need to apply them daily for several weeks, or even months, before you see significant changes.
Deeper Exfoliation With Professional Peels
If you're looking for more dramatic results than what creams alone can offer, professional treatments can really kick things up a notch. Chemical peels, for instance, use stronger concentrations of acids to deliver a much deeper level of exfoliation.
A series of controlled, professional peels can effectively lift away the top layers of hyperpigmented skin. This process not only removes the discolouration but also encourages new cell growth, leading to a much smoother and more even complexion.
This can be a great way to complement your at-home routine and speed things along. To see if it's the right fit for you, you can explore the benefits of chemical peels at Skinsation Aesthetics and get a professional opinion.
Addressing the Root Cause With Oral Medications
Sometimes, treating the surface of the skin isn't enough. A healthcare professional might suggest oral medications to get at the underlying cause of AN, especially when insulin resistance is the main culprit.
One of the most frequently prescribed medications in Canada for this is Metformin. It works by making your body more sensitive to insulin. This helps lower the high insulin levels that were triggering the skin changes in the first place, allowing the dark patches to gradually fade.
There are also other medical options to consider, especially when conditions like obesity and insulin resistance are involved. For example, some newer medications are proving to be very effective; a great resource on GLP-1 for weight loss explains how these types of treatments work.
Whether you're starting a new cream or an oral medication, it’s so important to have professional guidance. Always chat with your doctor or a skin specialist to make sure you're using the right products for your unique situation and to set realistic expectations for your journey to clearer skin.
How Aerolase Offers a Modern Treatment Solution

While lifestyle changes and topical creams are fantastic first steps, they often demand months of perfect, unwavering consistency before you see real changes. For anyone looking for a more direct and faster way to improve the appearance of AN, modern laser therapy is a powerful ally. Here at Skinsation Aesthetics in London, Ontario, we specialize in a leading-edge acanthosis nigricans treatment using the Aerolase Neo Elite laser, which we believe is the top solution available today.
This isn’t just any laser. What makes Aerolase so different is its unique 650-microsecond pulse technology. This feature allows the laser energy to zip through the skin so quickly that it zeroes in on the excess pigment (melanin) and thickened tissue of AN, all without overheating and harming the surrounding skin.
This precision is what makes Aerolase a genuine game-changer, especially for our diverse Canadian clients who are understandably concerned about the hyperpigmentation risks that can come with other lasers.
Safe for All Skin Tones
One of the biggest hurdles in treating pigmentation is finding a solution that’s truly safe for every skin colour. Many traditional lasers can actually trigger post-inflammatory hyperpigmentation, a risk that’s higher for individuals with darker skin tones—the very same people often affected by acanthosis nigricans.
Aerolase neatly sidesteps this entire problem. Its pulse duration is shorter than the skin's "thermal relaxation time," which is a technical way of saying the skin has a chance to cool down between pulses.
This critical difference makes the Aerolase Neo Elite exceptionally safe and effective for all skin types on the Fitzpatrick scale, from the fairest to the deepest tones. It gives us the confidence to treat AN without the usual worries about side effects.
This incredible safety profile is a huge reason why we’ve made it a cornerstone of our practice at Skinsation Aesthetics. Everyone deserves to feel good in their skin, and that means having access to treatments that work without compromise.
What to Expect During an Aerolase Session
Many people hear "laser" and immediately think "pain," but the Aerolase experience is refreshingly different. Because the energy is delivered in such a rapid, gentle way, most of our clients just describe the feeling as a mild warmth on their skin. It’s a very tolerable and comfortable procedure.
A typical Aerolase session for acanthosis nigricans is also surprisingly quick, usually taking only 15 to 30 minutes, depending on the size of the area we’re treating. It's an easy appointment to fit into even the busiest of schedules.
And maybe the best part for our clients? There is absolutely no downtime. You can walk out of our London, Ontario clinic and get right back to your day—no recovery period required.
Beyond Fading: A Dual-Action Approach
Aerolase does much more than just lighten the dark patches of AN. Its energy directly targets and shatters the excess melanin causing the discolouration. Over a series of treatments, your body's own immune system naturally clears away this pigment, leading to a much lighter, more even-toned appearance.
But the benefits go even deeper, right into the skin's structure.
The laser energy gently warms the dermis (the deeper layer of your skin), which kicks your body’s collagen production into high gear. Collagen is the protein that gives skin its strength and elasticity. This dual action means Aerolase doesn't just fix the pigmentation; it also smooths out that thick, velvety texture associated with acanthosis nigricans.
Here’s a quick look at the benefits:
Reduces Hyperpigmentation: Directly targets and breaks down excess melanin deposits.
Improves Skin Texture: Stimulates collagen remodelling to soften the thickened, velvety skin.
Minimal Discomfort: The unique 650-microsecond pulse technology makes the treatment feel comfortable.
No Downtime: You can get back to your normal activities right after your session.
The end result is skin that isn’t just lighter, but also noticeably smoother, healthier, and more refined. That’s a level of improvement that topical creams on their own just can't match. To get a better sense of the science behind it all, you can learn more about **our Aerolase technology** and see how it’s setting a new standard for skin rejuvenation. By bringing this advanced laser into a complete treatment plan, we can achieve incredible cosmetic improvements much more effectively.
Creating Your Integrated Treatment Plan for Best Results
When it comes to treating acanthosis nigricans, we've found that a one-size-fits-all approach just doesn't cut it. Lasting success isn't about a single magic cream or treatment. It’s about building a smart, integrated strategy that tackles the issue from the inside out, with Aerolase as the premier cosmetic solution.
Think of it this way: you pair the powerful, insulin-stabilizing benefits of a healthier diet with a series of targeted Aerolase laser treatments right here at Skinsation Aesthetics. While your lifestyle adjustments are working behind the scenes to manage the root cause and stop new patches from forming, the laser gets to work on the surface. It clears away existing discolouration and smooths out that velvety texture far faster than any topical cream could on its own.
This two-pronged attack is really the secret sauce for seeing quick improvements while setting yourself up for long-term control.
The Synergy of Lifestyle and Laser
Let’s walk through a real-world scenario. A client from here in London, Ontario, comes to see us, worried about the dark, thick skin on their neck and underarms. After a thorough consultation, we confirm it’s acanthosis nigricans tied to insulin resistance.
Their personalized plan would look something like this:
Building a Strong Foundation: They start by making those key dietary and activity changes we talked about. This is all about stabilizing their insulin levels—the absolute most important first step.
Speeding Up the Visible Results: At the same time, they begin a course of Aerolase treatments. The laser immediately starts targeting the excess pigment and improving the skin's rough texture.
Within just a few weeks of their first laser session, they start to see their skin getting lighter and feeling smoother. That visible progress is a huge motivator! It makes sticking with the new healthy habits feel so much more rewarding. This powerful synergy is what makes an integrated plan work so well—each piece of the puzzle supports and boosts the other.
This visual breaks down the three core lifestyle changes that form the bedrock of managing acanthosis nigricans.

As you can see, it’s a sequence where diet, exercise, and weight management all work together to address what’s triggering the AN internally.
Customizing Your Path Forward
No two people are the same, and your treatment plan shouldn't be either. The best approach is always a partnership between professional guidance and your own personal commitment. A specialist can help you nail down the precise cause and map out the most effective treatments, but it's your daily choices that will ultimately maintain those beautiful results.
This holistic method ensures you're doing more than just masking a symptom. You're actively building a foundation for healthier skin and better overall wellness that will benefit you for years.
By combining an internal focus on health with an external focus on skin rejuvenation, you create a powerful cycle of positive reinforcement. As your skin clears up with Aerolase, you feel more motivated to continue the lifestyle habits that prevent it from coming back.
At Skinsation Aesthetics, creating these personalized strategies is what we do best. We use Aerolase not just to treat what's on the surface, but to complement the deeper health changes our clients are making. This combined approach is truly the gold standard for achieving the clear, even-toned skin you deserve. You can see exactly how we use this advanced laser for pigmentation issues by reading about our specific **Aerolase treatment for hyperpigmentation**.
Ultimately, a successful plan comes down to teamwork—a partnership between you and your skincare professional. By working together and combining the best of lifestyle management with advanced technology like Aerolase, you can achieve incredible, lasting improvements.
Your Questions About Acanthosis Nigricans Answered
It's completely normal to have a lot of questions when you're dealing with a new skin concern. To give you some clarity, we've put together answers to the most common queries we hear from our clients about acanthosis nigricans. This should help build on what you've learned and let you take the next steps with confidence.
How Long Until I See Results From My AN Treatment?
The honest answer is, it really depends on the path you choose. Every approach works on a different timeline, and from our experience, combining them is what truly gets the best results.
If you’re focusing on lifestyle changes like diet and exercise, you’ll likely see a gradual lightening of the skin over several months. It’s a slow and steady process. With topical creams, like retinoids or those containing urea, you're looking at about 6 to 8 weeks of consistent daily use before you start to see subtle shifts in skin texture and colour.
For clients wanting more noticeable cosmetic improvements faster, an advanced acanthosis nigricans treatment like Aerolase can make a visible difference after just a few sessions. For the fastest, most comprehensive results, we always recommend pairing Aerolase treatments with those positive lifestyle changes.
Is Aerolase Treatment Painful Or Risky For My Skin Tone?
This is such an important question, and the answer is one of the biggest reasons we love the Aerolase laser. Most people describe the sensation as a gentle warmth on the skin—it’s very comfortable and easy to tolerate.
A standout benefit of the Aerolase Neo Elite technology we use at Skinsation Aesthetics is its incredible safety profile. It’s proven to be safe and effective for all skin types and tones. This is especially crucial for AN, which often affects deeper skin tones that can be more prone to complications from other types of lasers.
Best of all, there’s no downtime. You can walk out of our London, Ontario clinic and get right back to your day.
Can Acanthosis Nigricans Return After Treatment?
Yes, it's possible for AN to come back if the root cause isn't managed over the long term. Since acanthosis nigricans is really just a symptom of something else going on inside your body, its return is tied directly to that trigger.
For instance, if insulin resistance is the main driver, going back to old eating habits that cause insulin spikes could make the skin darken again. This is exactly why a holistic, well-rounded treatment plan is so vital.
Aerolase can do a beautiful job of clearing the existing pigmentation and smoothing out the skin's texture, but a healthy lifestyle is what keeps it from coming back. Think of the laser as resetting your skin, and your daily habits as the key to maintaining that clear, healthy state.
This one-two punch of advanced treatment and sustainable lifestyle management gives you the best defence against a recurrence.
Do I Need A Doctor's Referral For Aerolase At Skinsation Aesthetics?
No, you don’t need a doctor’s referral to come and see us. We welcome you to book a consultation directly at our Skinsation Aesthetics clinic right here in London, Ontario.
During your visit, one of our skilled specialists will take a close look at your skin, listen to all your concerns, and chat about your goals. We’ll figure out if Aerolase is the right acanthosis nigricans treatment for your unique situation and work with you to design a personalized plan to help you get the clear, smooth, and healthy-looking skin you deserve.
Ready to take the next step towards clearer, more confident skin? At Skinsation Aesthetics, we specialize in advanced treatments like Aerolase to provide effective, safe, and comfortable solutions for acanthosis nigricans. Book your consultation today to create a personalized plan that works for you. https://www.skinsation.me


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