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Our Aerolase Technology

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Aerolase Neo: How the 650-Microsecond 1064-nm Laser Became the Gold Standard Patients Trust

 

Modern laser dermatology asks a lot from a single device: it has to be powerful without being painful, precise without being risky, and inclusive for every skin tone. The Aerolase Neo (often seen in its Neo Elite configuration) delivers on all three—by pairing a deeply penetrating 1064-nm Nd:YAG wavelength with an ultra-short 650-microsecond pulse. That engineering choice is more than a spec-sheet flex; it’s the reason clinicians can treat acne, redness, pigment, hair, and more—with comfort, consistency, and confidence across Fitzpatrick I–VI.

 

Below is a comprehensive look at the technology, the clinical evidence, and the practical advantages that make Aerolase Neo a best-in-class platform—and why so many patients and providers prefer it over other aesthetic lasers.

The Technology: 1064-nm Nd:YAG + 650-Microsecond Pulse

 

Two ideas underpin Aerolase Neo:

  1. Selective photothermolysis—deliver light that is preferentially absorbed by a target (pigment, hemoglobin, or follicular melanin), and deliver it in pulses shorter than the target’s thermal relaxation time so heat stays where you want it. This principle—first formalized by Anderson and Parrish—continues to guide safe, effective laser design today. 

  2. Wavelength matters—the 1064-nm Nd:YAG wavelength penetrates more deeply and is absorbed less by epidermal melanin than shorter wavelengths (532/694/755 nm). That reduced melanin absorption is a major reason long-pulsed Nd:YAG is considered the most forgiving, and often the safest, option for darker skin tones (IV–VI).

 

Where Aerolase innovates is pulse duration. Many legacy Nd:YAG systems fire in milliseconds. Neo delivers high energy in a 650-microsecond pulse—shorter than the thermal relaxation time of surrounding skin—so heat remains confined to the target while the epidermis has time to cool, improving efficacy and safety.

In practice, that translates to:

  • Effective targeting of acne bacteria, inflamed vessels, pigment, and follicles

  • Less unintended epidermal heating, which helps minimize discomfort and risk of post-inflammatory hyperpigmentation

  • No skin contact, no chilling gel, and typically no topical anesthetic—hallmarks of the Neo experience patients rave about

What It Treats—and Why It’s So Versatile

 

The Aerolase Nd:YAG platform is FDA-cleared (via 510(k)) for a wide range of dermatologic indications: vascular and pigmented lesions (e.g., rosacea, telangiectasias, leg veins, lentigines), wrinkles, acne (mild to moderate inflammatory), hair reduction including PFB, and more. Importantly, it’s cleared for use on all skin types, Fitzpatrick I–VI—including tanned skin.

 

In everyday aesthetics, that breadth shows up as:

  • Acne & inflammatory lesions

  • Melasma, sun spots, and PIH

  • Rosacea, broken capillaries, and diffuse redness

  • Skin rejuvenation (collagen stimulation, tone/texture)

  • Hair reduction including on deeper skin tones and PFB-prone areas

Aerolase summarizes this versatility as “30+ (often cited as 36+) indications” on a single, compact device—one reason clinics can replace multiple platforms with one workhorse.

Comfort and Safety: Why Patients Say It “Feels Different”

 

Patients often describe Neo sessions as surprisingly tolerable compared with older lasers or energy-based devices. That’s the 650-microsecond difference at work:

  • Short pulses reduce heat spread and nociceptor activation, cutting the sting that typically requires cooling, gel, or numbing with other systems.

  • Non-contact delivery avoids pressure or dragging sensations.

  • Inclusive by design—the combination of 1064 nm and a very short pulse supports safe treatment across all skin tones when used appropriately.

For anyone who has avoided lasers because of pain, downtime, or fear of pigmentation changes, this is a meaningful shift in the treatment experience.

Clinical Evidence Patients Can Trust

 

Acne vulgaris

Peer-reviewed data support the Neo approach to acne. In a prospective JDD study (2024) using the Neo Elite’s 650-microsecond, 1064-nm Nd:YAG, subjects (Fitz I–VI) received five treatments at two-week intervals:

  • Median lesion count reduction: ~48% after one session, ~84% by the third, sustained at ~87% at 90 days

  • Pain management: no anesthesia or cooling used

  • Safety: no adverse events observed across all skin types

  • Patient-reported outcomes: 90% were satisfied after three treatments and reported improved self-esteem as the series progressed

 

The authors concluded the device delivered long-lasting clearance with high satisfaction and without adverse effects across skin tones.

Earlier work—including a double-blind randomized controlled study—described how delivering high energy in a 650-microsecond pulse confines heat to the target, achieving higher target temperatures while allowing skin to cool between pulses—a mechanism that helps explain efficacy with comfort.

Hair reduction, including on dark skin

Independent literature has long shown that long-pulsed 1064-nm Nd:YAG is an effective, safer choice for hair removal on darker phototypes compared with shorter-wavelength systems and IPL. One comparative study in darker skin found Nd:YAG more effective than IPL as judged by both subjects and clinicians.

Similarly, studies in Indian patients (skin of color) reported safe and effective hair reduction with long-pulsed 1064-nm Nd:YAG across multiple sessions.

These findings align with the physics: the longer 1064-nm wavelength bypasses much of the epidermal melanin, lowering the risk of burns and dyspigmentation that historically limited lasers for deeper skin tones.

Vascular & pigment

Because 1064 nm can target hemoglobin and melanin at useful depths, Neo tackles redness (rosacea/telangiectasias) and dyschromia (lentigines, PIH, melasma) while sparing the surface—again, a key reason it’s usable on a wide array of skin tones. Specialty publications and clinic reports consistently position Neo Elite as a “workhorse” for physicians treating diverse concerns in all skin types.

Why Aerolase Neo Often Outperforms “Traditional” Options

 

1) One device, many jobs
Practices adopt Neo because it consolidates acne, redness, pigment, rejuvenation, hair reduction, and more into one platform. Clinically, that versatility means providers are less likely to “switch devices” mid-plan. Operationally, it means fewer consumables and simpler room turnover. 

2) Superior inclusion
Many laser platforms still segment candidacy by skin tone. Neo’s 1064-nm wavelength and 650-microsecond pulse design are purpose-built to treat Fitzpatrick I–VI, supporting equitable access to care. Patients notice—and trust—platforms that welcome them without caveats. 

3) Comfort without compromise
Numbing creams, chilled air, contact gels, and “downtime days” are common with older equipment. The Neo experience is typically gel-free, no-numbing, and low-downtime while still hitting clinical endpoints—an advantage for busy schedules and sensitive skin. 

4) Evidence for outcomes that matter
From acne clearance and recurrence control to hair reduction on highly melanated skin, the literature framework around 1064-nm Nd:YAG—and specifically 650-microsecond delivery—supports both efficacy and safety. 

5) Regulatory clarity
FDA 510(k) clearance across a wide range of dermatologic uses—explicitly including all skin types—gives providers and patients confidence in the device’s intended use and safety profile.

Neo vs. IPL and Other Lasers: A Short, Honest Comparison

  • IPL (intense pulsed light) is broadband, not a laser. While useful, its energy is less specific than a monochromatic 1064-nm beam, and studies in darker skin show Nd:YAG often achieves better efficacy with a more favorable safety margin. 

  • Shorter-wavelength lasers (532/694/755 nm) can be excellent for select targets and lighter phototypes, but their higher epidermal melanin absorption raises risk in skin of color—demanding more conservative settings or exclusion. Neo’s 1064-nm minimizes that epidermal absorption. 

  • Legacy long-pulsed Nd:YAG devices are effective, but many rely on millisecond pulses and heavy cooling/numbing to manage pain. Neo’s 650-microsecond pulse confines heat more efficiently, often enabling contactless, gel-free comfort without sacrificing results.

Trust Is Earned: Why Patients (and Providers) Choose Neo

 

Consistent outcomes across tones. Patients who were once told they “weren’t candidates” now see meaningful improvements in acne, discoloration, redness, and texture—without trading results for safety. That consistency builds word-of-mouth trust rapidly.

Comfortable experience. Fewer protective measures, less sting, and minimal downtime turn first-timers into loyalists—especially those with sensitive or reactive skin. 

 

Evidence + credentials. FDA clearance for broad indications and peer-reviewed data—especially in acne—reassure patients that Neo isn’t a fad; it’s a rigorously evaluated platform. 

 

Physician adoption. Dermatology publications describe Neo Elite as a “workhorse” that slots into both medical and aesthetic workflows—an endorsement that matters when people are choosing where to invest their time and trust.

What a Typical Course Looks Like

 

Treatment plans vary by concern, but many protocols involve 3–6 sessions, spaced 2–4 weeks apart, with maintenance as needed—especially for chronic conditions like melasma or rosacea. Sessions are brief (often under 30 minutes), and most patients resume normal activity immediately. Always follow your provider’s pre/post-care (sun avoidance, gentle skincare, no photosensitizing topicals) to maximize results.

The Bottom Line

 

If you had to summarize why Aerolase Neo is widely considered best-in-class, it comes down to three things:

  1. Physics designed for people: 1064-nm depth with 650-microsecond precision confines heat to the target while sparing surface skin—delivering efficacy and comfort.

  2. Evidence that holds up: FDA clearance for all skin types and peer-reviewed outcomes—especially in acne—validate what patients feel in the chair.

  3. Versatility without trade-offs: From acne to angiomas, melasma to hair reduction, Neo covers 30+ aesthetic and medical indications in one compact platform, often without gel, cooling, or numbing.

 

That rare blend of inclusive safety, clinic-level performance, and patient-friendly comfort is why Aerolase Neo has become the device people ask for by name—and why providers reach for it first.

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